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About three-quarters of patients with RLS also have osteoarthritis, a common condition affecting older adults.
It has already been suggested that this disorder is a manifestation of decreased dopamine activity at striatal dopamine receptors and that such decreased activity results in most patients from decreased dopamine released from nigrostriatal dopaminergic neurons: presynaptic dopamine deficiency.
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This would be coupled with the added benefit of increased compliance with treatment as a combination would ensure all the three drugs would be taken and a possible reduction in cost of therapy.
The cause or causes of periodic limb movement disorder (PLMD) are not clear.
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In the outpatient setting it is used for maintenance therapy in patients previously treated with antipsychotic drugs.
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In placebo-controlled trials, there was a significantly higher incidence of cerebrovascular adverse events in patients treated with risperidone compared to patients treated with placebo.
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Of the 10 patients who were improved on bromocriptine therapy six have continued to show improvement six months after initiation of the drug, although the improvement has diminished in four because the dose of the drug had to be decreased.
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In less than 2% of cases, DBS has no effect and symptoms fail to improve, either due to malpositioned electrodes or because of an incorrect diagnosis.
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In vitro studies demonstrated that drugs metabolized by other CYP isozymes, including 1A1, 1A2, 2C9, 2C19, and 3A4, are only weak inhibitors of risperidone metabolism.
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MAO inhibisyonu, yüksek oranda tiramin içeren besinler alýndýðýnda ortaya çýkan “cheese effect” (peynir etkisi) denilen hipertansif krizler ve serotonin sendromuna yol açabilir.
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Excessive daytime sleepiness results from nighttime sleeplessness due to RLS or PLMD symptoms).
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