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Treatment with multiple antipsychotics or long acting injectable antipsychotic at baseline is not excluded, but will be reviewed by the MAG to assess appropriateness for the study.
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It is recommended that persons with dementia who exhibit behavioral and psychological symptoms should not be given antipsychotics before trying other treatments.
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Diga a su doctor sobre todas las medicinas que usted toma y sobre todo: benzodiazepines (lorazepam) u otras medicinas para problemas mentales o de humor porque el riesgo de problemas de corazón o respiración puede ser aumentado; cimetidine, erythromycin, antibióticos de quinolone(ciprofloxacin), risperidone, o inhibidores de la recaptación de serotonina (SSRIs) (por ej, fluoxetine) porque ellos pueden aumentar el riesgo de los efectos secundarios de Clozaril; los barbitúricos (fenobarbital), hydantoins (phenytoin), nicotina, o rifampin porque ellos pueden disminuir la eficacia de Clozaril; el antiaritmicos (por ej, propafenone, quinidine), anticholinergics (benztropine), carbamazepine, debrisoquin, dextromethorphan, medicinas para depresión o hipertensión, phenothiazines (chlorpromazine), o antidepresivos triciclicos (amitriptyline) porque el riesgo de sus efectos secundarios puede ser aumentado por Clozaril.
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All participants were assessed prospectively at baseline and every 6 months over 3 years for psychiatric symptoms and substance use.
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Alternatively certain antidepressants, such as bupropion (Wellbutrin) and sertraline (Zoloft) may be helpful in some individuals.
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It is then absorbed systemically, causing a sudden release of large amounts of norepinephrine.
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Neuroleptic malignant syndrome has been reported to be more common in males, although that most likely reflects greater neuroleptic usage rather than greater susceptibility.
NDMC and clozapine on muscarinic receptors, and observed that NDMC displayed high potency and significant agonist efficacy at multiple muscarinic receptor subtypes, most notably the M 1 receptor.
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The realisation that antipsychotics treatment of any kind can have profound side-effects has led to something of an explosion in the monitoring considered necessary.
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Clozapine plasma concentrations are not clinically useful or readily available.
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Generally, the amount of clozapine in a sample is determined by correlating the measured amount of the bound or unbound conjugate produced by the clozapine in the sample with values of the bound or unbound conjugate determined from standard or calibration curve obtained with samples containing known amounts of clozapine, where known amounts are in the range expected for the sample to be tested.
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Yonkman, a chemist at the Swiss-based company, first used the term tranquilizer to differentiate from the older sedatives.
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Medicaid recipients, many are treated in state-run hospitals, and patients with schizophrenia are more likely to be non-compliant with pharmacotherapy than patients without schizophrenia (In the case of schizophrenia, non-compliance is attributed to the fact that patients with schizophrenia do not understand their condition).
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