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Diga a su doctor sobre todas las medicinas que usted toma y sobre todo: benzodiazepines (lorazepam) u otras medicinas para problemas mentales o de humor porque el riesgo de problemas de corazón o respiración puede ser aumentado; cimetidine, erythromycin, antibióticos de quinolone(ciprofloxacin), risperidone, o inhibidores de la recaptación de serotonina (SSRIs) (por ej, fluoxetine) porque ellos pueden aumentar el riesgo de los efectos secundarios de Clozaril; los barbitúricos (fenobarbital), hydantoins (phenytoin), nicotina, o rifampin porque ellos pueden disminuir la eficacia de Clozaril; el antiaritmicos (por ej, propafenone, quinidine), anticholinergics (benztropine), carbamazepine, debrisoquin, dextromethorphan, medicinas para depresión o hipertensión, phenothiazines (chlorpromazine), o antidepresivos triciclicos (amitriptyline) porque el riesgo de sus efectos secundarios puede ser aumentado por Clozaril.

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Neuroleptic malignant syndrome has been reported to be more common in males, although that most likely reflects greater neuroleptic usage rather than greater susceptibility.

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